منابع مشابه
From screens to genes: prospects for insertional mutagenesis in zebrafish.
The systematic, and now classic, genetic screens for mutations affecting the development of Drosophila and Caenorhabditis elegans have laid the foundation for the study of developmental mechanisms in these invertebrates (N/isslein-Volhard and Wieschaus 1980; Horvitz and Sternberg 1991). The subsequent molecular isolation and characterization of the affected genes has allowed a thorough understa...
متن کاملA large-scale insertional mutagenesis screen in zebrafish.
It is estimated that approximately 2500 genes are essential for the normal development of a zebrafish embryo. A mutation in any one of these genes can result in a visible developmental defect, usually followed by the death of the embryo or larva by days 5-7 of age. We are performing a large-scale insertional mutagenesis screen in the zebrafish with the goal of isolating approximately 1000 embry...
متن کاملTransposon insertional mutagenesis in rice.
Plant Research International, P.O. Box 16, 6700 AA Wageningen, The Netherlands (R.G., A.P); Institute of Molecular Plant Sciences Leiden University, The Netherlands (P.B.F.O., J.H.C.H); Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Montpellier, France (C.S., E.G.); John Innes Centre, Norwich, United Kingdom (A.K., P.C.); University of Milan, Italy (L.C.); ...
متن کاملAAV and Insertional Mutagenesis.
editorial I n this issue of Molecular Therapy, David Rus-sell provides an invited commentary on data presented at the tenth annual meeting of the American Society of Gene Therapy that strongly suggested that adenovirus-associated virus (AAV) vector insertion could in certain models be linked to the development of cancer. 1 A short report describing the data that are the subject of this commenta...
متن کاملInsertional mutagenesis of pathogenic fungi.
Screening insertional mutants for loss of virulence is an effective method for investigating the molecular genetic basis of bacterial pathogenesis, but has only recently been applied to fungal pathogens. For many pathogenic fungi transformation with heterologous plasmid DNA results in complex integration events. This problem can now be circumvented for some species using restriction enzyme medi...
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ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 2003
ISSN: 1058-8388,1097-0177
DOI: 10.1002/dvdy.10381